OXADIAZOLE-BASED PIPERAZINE DERIVATIVES AND APPLICATIONS THEREOF

摘要

Disclosed are acethydrazide derivatives containing oxadiazole-based piperazine represented by the general formula I, geometric isomers thereof as well as pharmaceutically acceptable salts, hydrates or solvates thereof, which belong to the technical field of medicines. In formula I, substituent groups Ar1 and R1 have definitions given in the description. Methods for preparing the compounds of formula I, medicinal compositions containing the compounds as well as applications of the compounds for preparing medicines for treating and/or preventing cancers and other hyperplastic diseases are also disclosed.