The invention provides monoclonal antibodies that specifically bind to CD122, which is one component of receptors for IL-2 and IL-15. The monoclonal antibodies have the capacity for substantial inhibition of both IL-2 and IL-15 mediated functions by inhibiting binding of these cytokines to their receptors. The monoclonal antibodies can be used for inhibiting undesired immune responses or treatment of cancer, among other applications.
申请公布号
WO2011127324(A2)
申请公布日期
2011.10.13
申请号
WO2011US31640
申请日期
2011.04.07
申请人
JN BIOSCIENCES, LLC;TSO, J. YUN;TSURUSHITA, NAOYA;LANDOLFI, NICHOLAS F.;KUMAR, SHANKAR
发明人
TSO, J. YUN;TSURUSHITA, NAOYA;LANDOLFI, NICHOLAS F.;KUMAR, SHANKAR