发明名称 |
METHOD OF DESIGNING siRNAS FOR GENE SILENCING |
摘要 |
The present invention provides a method for identifying siRNA target motifs in a transcript using a position-specific score matrix approach. The invention also provides a method for identifying off-target genes of an siRNA using a position-specific score matrix approach. The invention further provides a method for designing siRNAs with higher silencing efficacy and specificity. The invention also provides a library of siRNAs comprising siRNAs with high silencing efficacy and specificity.
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申请公布号 |
US2011250591(A1) |
申请公布日期 |
2011.10.13 |
申请号 |
US201113100836 |
申请日期 |
2011.05.04 |
申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
JACKSON AIMEE L.;BARTZ STEVEN R.;BURCHARD JULJA;LINSLEY PETER S.;GE WEI;CAVET GUY L. |
分类号 |
C12Q1/68;C12N;C12N15/11;G06F19/22 |
主分类号 |
C12Q1/68 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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