发明名称 |
BIOLUMINESCENCE IMAGING OF MYELOPEROXIDASE ACTIVITY IN VIVO, METHODS, COMPOSITIONS AND APPARATUSES THEREFOR |
摘要 |
Methods of imaging distribution of myeloperoxidase activity in a subject are disclosed. These methods include the use of bioluminescent substrates, including luminol and wavelength-shifted analogues of luminol. Bioluminescent myeloperoxidase substrates that emit light at longer wavelengths compared to luminol are shown to be useful for imaging myeloperoxidase activity in vivo. The disclosed methods can be used for imaging sites of inflammation and other pathological conditions associated with abnormal levels of MPO activity in vivo. Methods of synthesis of luminol analogues are also disclosed.
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申请公布号 |
US2011250145(A1) |
申请公布日期 |
2011.10.13 |
申请号 |
US200913127448 |
申请日期 |
2009.11.03 |
申请人 |
WASHINGTON UNIVERSITY |
发明人 |
SHARMA VIJAY;GAMMON SETH;PIWNICA-WORMS DAVID;GROSS SHIMON |
分类号 |
A61K49/00;C07D237/32;C07D403/14;C07D405/12;C07D413/14;C07D491/22 |
主分类号 |
A61K49/00 |
代理机构 |
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地址 |
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