The present invention provides a process for producing lipid nanoparticles encapsulating therapeutic products, said process comprising: a) providing one or more aqueous solutions in one or more reservoirs; b) providing one or more organic solutions in one or more reservoirs, wherein one or more of the organic solutions contains a lipid and wherein one or more of the aqueous solutions and/or one or more of the organic solutions includes therapeutic products; c) mixing said one or more aqueous solutions with said one or more organic solutions in a first mixing region, wherein said first mixing region is a Multi-Inlet Vortex Mixer (MIVM), wherein said one or more aqueous solutions and said one or more organic solutions are introduced tangentially into a mixing chamber within the MIVM so as to substantially instantaneously produce a lipid nanoparticle solution containing lipid nanoparticles encapsulating therapeutic products.
申请公布号
WO2011127255(A1)
申请公布日期
2011.10.13
申请号
WO2011US31540
申请日期
2011.04.07
申请人
MERCK SHARP & DOHME CORP.;THE TRUSTEES OF PRINCETON UNIVERSITY;BURKE, PAUL, A.;GINDY, MARIAN, E.;KUMAR, VARUN;MATHRE, DAVID, J.;PRUD'HOMME, ROBERT, K.
发明人
BURKE, PAUL, A.;GINDY, MARIAN, E.;KUMAR, VARUN;MATHRE, DAVID, J.;PRUD'HOMME, ROBERT, K.