摘要 |
In an embodiment the instant invention discloses a modular composition comprising 1) an oligonucleotide; 2) one or more linkers, which may be the same or different, selected from Table 1, wherein the linkers are attached to the oligonucleotide at any 3' and/or 5' end; 3) one or more peptides, which may be the same or different, selected from SEQ ID NOs: 1-59, wherein the peptides are attached to the linkers; and optionally one or more lipids, solubilizing groups and/or targeting ligands attached to the oligonucleotide.
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申请人 |
MERCK SHARP & DOHME CORP. |
发明人 |
AARONSON, JEFFREY G.;BARNETT, STANLEY F.;BARTZ, RENE;COLLETTI, STEVEN L.;JADHAV, VASANT R.;MOMOSE, AARON A.;SHAW, ANTHONY W.;TELLERS, DAVID M.;TUCKER, THOMAS J.;WANG, WEIMIN;YUAN, YU |