<p>A fibrin/fibrinogen binding a depot for the sustained release of a pharmaceutically active substacne from a fibrin clot. The conjugates comprises a fibrin/fibrinogen binding moiety bound to a pharmaceutically active substance either directly or via an intervening substance capturing moiety such as an antibody. The conjugate can also be a recombinant fusion protein comprising a fibrin/fibrinogen binding moiety such as VEGF185C-terminal domain fused to a wound-healing substance such as leptin.</p>
申请公布号
EP2168981(A3)
申请公布日期
2011.10.12
申请号
EP20090004993
申请日期
2001.09.25
申请人
BAXTER INNOVATIONS GMBH;BAXTER INTERNATIONAL INC. (A DELAWARE CORPORATION)