发明名称 TRIVALENT, BISPECIFIC ANTIBODIES.
摘要 <p>The present invention relates to trivalent, bispecific antibodies, methods for their production, pharmaceutical compositions containing said antibodies, and uses thereof. The trivalent, bispecific antibodies of the invention comprise a full length antibody specifically binding to a first antigen and consisting of two antibody heavy chains and two antibody light chains and a VH domain fused to the C-terminus of one of said heavy chains and a VL domain fused to the C-terminus of the other said heavy chains, wherein said VH domain and said VL domain together form an antigen-binding site specifically binding to a second antigen.</p>
申请公布号 MX2011010168(A) 申请公布日期 2011.10.11
申请号 MX20110010168 申请日期 2010.04.01
申请人 ROCHE GLYCART AG 发明人 EIKE HOFFMANN;ULRICH BRINKMANN;PABLO UMANA;CHRISTIAN KLEIN;REBECCA CROASDALE;EKKEHARD MOESSNER;JUERGEN MICHAEL SCHANZER;CLAUDIO SUSTMANN
分类号 C07K16/00;A61K39/395;C07K14/71;C07K16/28;C07K16/32;C07K16/46 主分类号 C07K16/00
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