发明名称 |
PROCESS FOR THE PREPARATION OF SUBSTITUTED CARBOXYLIC ACID ESTERS BY ENZYMATIC HYDROLYSIS |
摘要 |
A process for the preparation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by enzymatic hydrolysis, comprising the steps: a) enzymatic hydrolysis of racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters in aqueous and alkaline medium in the presence of an esterase; b) isolation of 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters by extraction with an organic solvent; c) isolation of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids from the aqueous-alkaline medium; d) Esterification of 2(R)-alkyl-5-halogenpent-4-ene carboxylic acids, e) subsequent racemization to form 2-alkyl-5-halogenpent-4-ene carboxylic esters; and f) return of the racemate obtained in step e) to step a), if necessary together with fresh racemic 2-alkyl-5-halogenpent-4-ene carboxylic esters. The process permits the undesired R-stereoisomers to be converted into the desired 2(S)-alkyl-5-halogenpent-4-ene carboxylic esters to avoid waste product from the synthesis.
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申请公布号 |
CA2445014(C) |
申请公布日期 |
2011.10.11 |
申请号 |
CA20022445014 |
申请日期 |
2002.04.26 |
申请人 |
SPEEDEL PHARMA AG |
发明人 |
STUTZ, STEFAN;HEROLD, PETER |
分类号 |
C12P7/00;C12P7/62;C12P41/00 |
主分类号 |
C12P7/00 |
代理机构 |
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地址 |
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