发明名称 |
Ultra-sensitive magnetoreduction measurement system and ultra-sensitive, wash-free assay using the same |
摘要 |
An ultra-sensitive, wash-free method for quantitatively determining the concentration of biomolecules in a sample solution is provided. The sensitivity of the method is 1 ppt or below. The method includes providing a reagent containing magnetic nanoparticles and measuring the ac magnetic susceptibility of the reagent. Then, a sample solution containing either multiple-active epitope biomolecules or single-active-epitope biomolecules is mixed with the reagent. The ac magnetic susceptibility of the reagent after the association with the biomolecules is measured. Thereafter, the difference in the ac magnetic susceptibility of the reagent before and after the association with the biomolecules is measured and the concentration of biomolecules in the sample solution is determined.
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申请公布号 |
US8034634(B2) |
申请公布日期 |
2011.10.11 |
申请号 |
US20070867207 |
申请日期 |
2007.10.04 |
申请人 |
HONG REX CHIH-YIH;HORNG HERNG-ER;YANG HONG-CHANG;YANG SHIEH-YUEH |
发明人 |
HONG REX CHIH-YIH;HORNG HERNG-ER;YANG HONG-CHANG;YANG SHIEH-YUEH |
分类号 |
G01N33/533;G01N33/543 |
主分类号 |
G01N33/533 |
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