发明名称 |
Engineered cleavage half-domains |
摘要 |
Disclosed herein are engineered cleavage half-domains; fusion polypeptides comprising these engineered cleavage half-domains; polynucleotides encoding the engineered cleavage half-domains and fusion proteins; and cells comprising said polynucleotides and/or fusion proteins. Also described are methods of using these polypeptides and polynucleotides, for example for targeted cleavage of a genomic sequence. |
申请公布号 |
US8034598(B2) |
申请公布日期 |
2011.10.11 |
申请号 |
US20090456857 |
申请日期 |
2009.06.23 |
申请人 |
SANGAMO BIOSCIENCES, INC. |
发明人 |
MILLER JEFFREY C. |
分类号 |
C12P21/06;C07H21/02;C07K1/00;C12N1/20;C12N9/22;C12N15/00 |
主分类号 |
C12P21/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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