发明名称 COMBINATION OF PYRIMIDYLAMINOBENZAMIDE AND IMANITIB DERIVATIVES FOR TREATMENT OR PREVENTION OF PROLIFERATIVE DISEASES
摘要 FIELD: medicine, pharmaceutics. ^ SUBSTANCE: there is presented a group of inventions including application of a combination of 4-methyl-3-[[4-(3-pyridinyl)-2-pyrimidinyl]amino]-N-[5-(4-methyl-1H-imidazole-1-yl)-3 (trifluoromethyl)phenyl]benzamide or its pharmaceutically acceptable salt, and imanitib or its pharmaceutically acceptable salt for preparing a drug intended for a method of treating gastrointestinal (G-I) stromal tumours. ^ EFFECT: use of the given combination for treating GI stromal tumours is clinically significant as opposed to single agent therapy due to a synergic effect of the preparations to ensure thereby a stable disease. ^ 2 cl, 1 ex, 1 tbl
申请公布号 RU2430727(C2) 申请公布日期 2011.10.10
申请号 RU20070147957 申请日期 2006.06.02
申请人 NOVARTIS AG 发明人 OLLAND LILA;MANLI POL U.;MESTAN JURGEN
分类号 A61K31/506;A61P35/00 主分类号 A61K31/506
代理机构 代理人
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