| 摘要 |
A biological artificial ligament having a fresh animal ligament or tendon as a substrate, and the substrate is pretreated with a sterilant and defatted, a specific active group in protein molecules of the ligament or tendon is blocked with an active reagent, a specific hydrogen bonding in the spiral chains of the protein molecules is replaced with a reagent with strong hydrogen bonding power, the protein molecule in the animal ligament or tendon is crosslinked with an epoxy compound, an acetyl diamide compound, a diisocyanate, or a carbodiimide, and an active layer having either a polypeptide or a glucosaminoglycan with capacity of adhering growth factors is coupled to the surface of the animal ligament or tendon by a coupling agent. A method of preparation of a biological artificial ligament is also provided.
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