CELL THERAPY TO IMPROVE WOUND HEALING AND RELATED COMPOSITIONS AND METHODS

摘要

Therapeutic compositions for improving wound healing and related methods of formulation and use are provided. The therapeutic compositions comprise a dosage of MSCs seeded to any one of a biodegradable matrix, a gel, or a solution suitable for subcutaneous injection. The dosage of MSCs may range from about 1X106 MSCs to about 1X1010 per administration. The administration regime may be daily, weekly, or monthly. The dosage and treatment intervals may be adjusted depending upon a patient's response to treatment. The therapeutic compositions may be co-administered, such as for example, topical application of a seeded matrix or gel combined with simultaneous or other recurring subcutaneous injection of MSCs.