发明名称 |
CELL-BASED DETECTION OF APF THROUGH ITS INTERACTION WITH CKAP4 FOR DIAGNOSIS OF INTERSTITIAL CYSTITIS |
摘要 |
An assay system designed to detect a protein biomarker in urine that is diagnostic for interstitial cystitis (IC). The presence of a 9 amino acid glycopeptide, antiproliferative factor (APF), in urine is unique to patients with IC. Urine samples from patients who exhibit symptoms consistent with IC are added to the assay system. Binding of APF to the cytoskeletal associated protein 4 (CKAP4) is positive for the presence of APF in urine and diagnostic for IC. The diagnostic system is a significant and surprising advance in diagnosis of IC and has commercial applications relevant to women and men who suffer from symptoms consistent with IC.
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申请公布号 |
US2011244493(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
US200913133244 |
申请日期 |
2009.12.10 |
申请人 |
THE COMMONWEALTH MEDICAL COLLEGE;UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. |
发明人 |
ZACHARIAS DAVID ALAN;PLANEY SONIA LOBO |
分类号 |
G01N33/566 |
主分类号 |
G01N33/566 |
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