发明名称 |
ANTIGEN-BINDING MOLECULES THAT PROMOTE ANTIGEN CLEARANCE |
摘要 |
An objective of the present invention is to provide methods for facilitating antigen-binding molecule-mediated antigen uptake into cells, methods for facilitating the reduction of antigen concentration in plasma, methods for increasing the number of antigens to which a single antigen-binding molecule can bind, methods for improving pharmacokinetics of antigen-binding molecules, antigen-binding molecules improved for facilitated antigen uptake into cells, antigen-binding molecules capable of facilitating the reduction of antigen concentration in plasma, antigen-binding molecules capable of repeatedly binding to antigens, antigen-binding molecules with improved pharmacokinetics, pharmaceutical compositions comprising such an antigen-binding molecule, and methods for producing those described above. The present inventors discovered that antigen uptake into cells is facilitated by an antibody having human FcRn-binding activity at the plasma pH and a lower antigen-binding activity at the early endosomal pH than at the plasma pH; such antibodies can increase the number of antigens to which a single antibody molecule can bind; the reduction of antigen in plasma can be facilitated by administering such an antibody; and antibody pharmacokinetics can be improved by using such antibodies. |
申请公布号 |
WO2011122011(A2) |
申请公布日期 |
2011.10.06 |
申请号 |
WO2011JP01888 |
申请日期 |
2011.03.30 |
申请人 |
CHUGAI SEIYAKU KABUSHIKI KAISHA;IGAWA, TOMOYUKI;ISHII, SHINYA;MAEDA, ATSUHIKO;NAKAI, TAKASHI |
发明人 |
IGAWA, TOMOYUKI;ISHII, SHINYA;MAEDA, ATSUHIKO;NAKAI, TAKASHI |
分类号 |
C07K16/00 |
主分类号 |
C07K16/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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