A METHOD OF MANUFACTURING (S)-5-METHOXY-2-[[(4-METHOXY-3,5-DIMETHYL-2- PYRIMIDINYL)METHYL]SULFINYL]-1H-BENZIMIDAZOLE USING A CHIRAL COMPLEX WITH MANDELIC ACID
摘要
<p>The invention deals with a new manufacturing method of (S)-5-methoxy-2-[[(4-methoxy- 3,5-dimethyl-2-pyridinyl)methyl]sulphinyl]-1H-benzimidazole of formula (I) and its salts of general formula (II), wherein the sulfide of general formula (III) is oxidized by hydroperoxides on a catalyst consisting of a chiral metallic complex containing ligands constituted by chiral functional derivatives of mandelic acid.</p>
申请公布号
WO2011120475(A1)
申请公布日期
2011.10.06
申请号
WO2010CZ00031
申请日期
2010.03.17
申请人
ZENTIVA, K.S.;STEPANKOVA, HANA;ZEZULA, JOSEF;HAJICEK, JOSEF;KRAL, VLADIMIR
发明人
STEPANKOVA, HANA;ZEZULA, JOSEF;HAJICEK, JOSEF;KRAL, VLADIMIR