ANTIBODIES WITH ENHANCED OR SUPPRESSED EFFECTOR FUNCTION
摘要
Rationally designed antibodies and polypeptides that comprise two Fc region amino acid substitutions that synergistically provide enhanced selectivity and binding affinity to a target Fc receptor are provided. The polypeptides comprise Fc region mutations at two positions that synergistically make the polypeptides more effective when incorporated in antibody therapeutics than those having wild-type Fc components.
申请公布号
CA2794745(A1)
申请公布日期
2011.10.06
申请号
CA20112794745
申请日期
2011.03.28
申请人
ZYMEWORKS, INC.
发明人
D'ANGELO, IGOR;BLEILE, DUSTIN;TOM-YEW, STACEY A. L.;ESCOBAR-CABRERA, ERIC;OHRN, ANDERS;POON, DAVID K. Y.;LARIO, PAULA I.;DIXIT, SURJIT B.