发明名称 |
COMPOSITIONS AND METHODS OF SYNTHESIS OF PYRIDINOYLPIPERIDINE 5-HT1F AGONISTS |
摘要 |
<p>The present invention provides a novel polymorph of the hemisuccinate salt of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide (Form A) characterized by a unique X-ray diffraction pattern and Differential Scanning Calorimetry profile, as well as a unique crystalline structure. This polymorph is useful in pharmaceutical compositions, for example, for the treatment and prevention of migraine. The invention also provides a process for the synthesis of pyridinoylpiperidine compounds of Formula I in high yield and high purity. In particular, the provides a process for the preparation of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamde, its hemisuccinate salt and polymorph (Form A).</p> |
申请公布号 |
WO2011123654(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
WO2011US30740 |
申请日期 |
2011.03.31 |
申请人 |
COLUCID PHARMACEUTICALS, INC.;CARNIAUX, JEAN-FRANCOIS;CUMMINS, JONATHAN |
发明人 |
CARNIAUX, JEAN-FRANCOIS;CUMMINS, JONATHAN |
分类号 |
C07D401/06;A61K31/444;A61P25/06 |
主分类号 |
C07D401/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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