PATCH PREPARATION CONTAINING BISOPROLOL

摘要

PROBLEM TO BE SOLVED: To provide a patch preparation well restrained in the decrease of drug content by generation of oozing and protrusion of the component of self-adhesive layer from the exposed area of the self-adhesive layer of the patch preparation in storage and oozing of bisoprolol or its salts from the self-adhesive layer.SOLUTION: Each shape of the flat surfaces of the patch preparation, a support, a peeling liner and the self-adhesive layer are made rectangle and a salient is made on the surface of the support at the edge of the rectangle of the patch preparation. It is also possible to make a central part and a peripheral part on the patch preparation and the salient is made at the corners of the rectangle of the central part, and further it is possible to make a built-up articulated portion having a thickness of thinner than that at the salient of the patch preparation between the neighboring not less than two salients. When a back split is made on the peeling liner, it must not go through the salient at the corner of the rectangle.