发明名称 |
Neutralizing Agents for Bacterial Toxins |
摘要 |
Stabilized variable regions of the T cell receptor and methods of making the same using directed evolution through yeast display are provided. In one embodiment, the variable region is variable beta. In one embodiment, the stabilized T cell receptor variable regions have high affinity for a superantigen, such as TSST-1 or SEB. These T cell receptor variable regions are useful as therapeutics.
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申请公布号 |
US2011245153(A1) |
申请公布日期 |
2011.10.06 |
申请号 |
US20070282193 |
申请日期 |
2007.03.15 |
申请人 |
NATIONAL INSTITUTES OF HEALTH (NIH), U. S. DEPT. OF HEALTH AND HUMAN RESOURCES (DHHS) U. S. GOVT. |
发明人 |
KRANZ DAVID M.;BUONPANE REBECCA A.;CHURCHILL HYWYN R.O.;SUNDBERG ERIC J.;MOZA BEENU;SCHLIEVERT PATRICK |
分类号 |
A61K38/17;A61P31/04;C07K14/725;C40B30/04 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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地址 |
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