NOTCH INHIBITION IN THE TREATMENT AND PREVENTION OF OBESITY AND METABOLIC SYNDROME

摘要

The present invention is directed to methods of treating or preventing or metabolic syndrome and its related disorders and complications by administering agents that inhibit the NOTCH signaling pathway. In addition, the invention encompasses methods determining whether a patient is at increased risk for developing these conditions the amount, function, or activity of NOTCH pathway components in biological samples derived from the patient or in imaging analyses.