发明名称 |
METHODS OF USING AGENTS THAT MODULATE CLAUDIN EXPRESSION |
摘要 |
Methods are provided for modulating expression of claudin-1 and/or claudin-23, for purposes of regulating formation of tight junctions in keratinocytes or other types of cells such as antigen presenting cells (e.g., dendritic cells and Langertians cells), by either increasing or decreasing expression of claudin-1 and/or claudin-23. Also provided are transdermal formulations that decrease expression of claudin- 1 and/or claudin-23, thereby diminishing tight junction formation in cells expressing claudin-1 and/or claudin-23, as well as a transdermal patch for delivering the same. |
申请公布号 |
WO2011097596(A3) |
申请公布日期 |
2011.10.06 |
申请号 |
WO2011US23951 |
申请日期 |
2011.02.07 |
申请人 |
UNIVERSITY OF ROCHESTER;BECK, LISA, A.;DE BENEDETTO, ANNA |
发明人 |
BECK, LISA, A.;DE BENEDETTO, ANNA |
分类号 |
A61K38/20 |
主分类号 |
A61K38/20 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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