发明名称 |
Analogs of benzoquinone-containing ansamycins for the treatment of cancer |
摘要 |
The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog. |
申请公布号 |
AU2004309395(B2) |
申请公布日期 |
2011.10.06 |
申请号 |
AU20040309395 |
申请日期 |
2004.12.23 |
申请人 |
INFINITY DISCOVERY, INC. |
发明人 |
GEORGES EVANGELINOS, ASIMINA T;GRENIER, LOUIS;ADAMS, JULIAN;PORTER, JAMES R;GAO, YUN;PAK, ROGER H;WRIGHT, JAMES L |
分类号 |
C07D211/60;A61P35/00;C07D225/06;C07D498/08;C07F5/02;C07F9/6561 |
主分类号 |
C07D211/60 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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