摘要 |
<p>The invention provides compounds for the treatment of sickle-cell disease. In particular, the invention provides 5-membered heterocyclic anti-sickling agents that are highly effective and nontoxic, and methods for their use. The compounds include analogues and derivatives of naturally occurring 5-hydroxymethyl-2-furfuraldehyde, 5-Ethyl-2-furfuraldehyde, 5-Methyl-2furfuraldehyde, and 2-furfuraldehyde, and prodrug forms of the compound.</p> |
申请人 |
VIRGINIA COMMONWEALTH UNIVERSITY |
发明人 |
SAFO, MARTIN, K.;DANSO-DANQUAH, RICHMOND;NOKURI, SAMUEL;MUSAYEV, FAIK, N.;JOSHI, GAJANAN, S.;BURNETT, JAMES, C.;ABRAHAM, DONALD, J. |