发明名称 METHOD FOR PRODUCING DIAMINE DERIVATIVE
摘要 <p>The present invention provides a method for producing a compound represented by formula (A), the method comprising the steps of: (a) mixing a compound represented by formula (B) with p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate at less than 1 molar equivalent with respect to the compound represented by formula (B) in a solvent under heating; (b) adding additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate to the mixed solution under cooling, wherein the additional p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate is added in such an amount that the total molar equivalent thereof with the p-toluenesulfonic acid or p-toluenesulfonic acid monohydrate of step (a) is 1 molar equivalent or more with respect to the compound represented by formula (B) of step (a); and (c) subsequently allowing the mixed solution to crystallize to obtain the compound represented by formula (A).</p>
申请公布号 EP2371830(A1) 申请公布日期 2011.10.05
申请号 EP20090833424 申请日期 2009.12.15
申请人 DAIICHI SANKYO COMPANY, LIMITED 发明人 KOYAMA, TAKEO
分类号 C07D513/04;A61K31/444;A61P7/02 主分类号 C07D513/04
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