发明名称 |
METHOD FOR THE SYNTHESIS OF PHOSPHORUS ATOM MODIFIED NUCLEIC ACIDS |
摘要 |
Described herein are methods of syntheses of phosphorous atom-modified nucleic acids comprising chiral X-phosphonate moieties. The methods described herein provide backbone-modified nucleic acids in high diasteteomeric purity via an asymmetric reaction of an achiral molecule comprising a chemically stable H-phophonate moiety with a nucleoside/nucleotide. |
申请公布号 |
EP2370451(A2) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20090808955 |
申请日期 |
2009.12.02 |
申请人 |
CHIRALGEN, LTD. |
发明人 |
WADA, TAKESHI;SHIMIZU, MAMORU |
分类号 |
C07H1/00;C07H21/00 |
主分类号 |
C07H1/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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