发明名称 |
TIMED PULSE RELEASE COMPOSITION |
摘要 |
<p>The present invention provides a timed pulse release composition comprising: a. a core composition comprising a therapeutically active agent, a swelling agent, and optionally water soluble compound(s) for inducing osmosis, and b. a coat composition comprising one or more film forming polymers, wherein upon imbibing fluid from the surrounding the core swells, and the coat ruptures to release in a pulse, the therapeutically active agent in a reliable manner at about a predetermined time wherein the reliable manner of rupture comprises rupturing of 36 tablets out of a total of 36 tablets at about the predetermined time when tested by subjecting the tablets to USP dissolution test using an aqueous media at 37±0.5oC, in a USP Type I or Type II apparatus at an rpm selected from the range of about 50 rpm to about 100 rpm.</p> |
申请公布号 |
EP1377276(B1) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20020733207 |
申请日期 |
2002.04.09 |
申请人 |
SUN PHARMA ADVANCED RESEARCH COMPANY LIMITED |
发明人 |
SHANGHVI, DILIP SHANTILAL;DHARMADHIKARI, NITIN BHALACHANDRA;ZALA, YASHORAJ RUPSINH;KHANNA, SATISH C. |
分类号 |
A61K9/24;A61K9/16;A61K9/36;A61K9/50;A61K31/155;A61K31/64;A61K45/06;A61K47/04;A61K47/30;A61K47/32;A61K47/36;A61K47/38;A61P1/12;A61P3/10;A61P5/00;A61P5/14;A61P5/38;A61P7/02;A61P9/00;A61P11/06;A61P11/14;A61P15/00;A61P15/08;A61P15/10;A61P17/00;A61P19/10;A61P25/02;A61P25/04;A61P25/06;A61P25/08;A61P25/16;A61P25/20;A61P25/28;A61P25/30;A61P25/32;A61P27/06;A61P29/00;A61P31/04;A61P35/00;A61P37/06;A61P37/08;A61P43/00 |
主分类号 |
A61K9/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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