发明名称 |
Method for producing granules |
摘要 |
<p>In a production process of granules containing a biologically active substance, variation in the elution profile of the biologically active substance is reduced by heating the temperature of granules to about 50°C or higher and maintaining the temperature for about 1 minute or longer. By setting the spray speed to about 90 mg/min or more per 1 g of cores when a spray agent for a primary agent containing the biologically active substance is sprayed while spraying a binding liquid to the cores and setting the total feeding weight per unit area for a centrifugal fluidized bed coating granulation machine to about 1.5 g/cm 2 or more, the variation in the elution profile of the biologically active substance from the granules is reduced.</p> |
申请公布号 |
EP2275088(A3) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20100175046 |
申请日期 |
2006.02.24 |
申请人 |
TAKEDA PHARMACEUTICAL COMPANY LIMITED |
发明人 |
NAGAHARA, NAOKI;ASAKAWA, NAOKI;NONOMURA, MUNEO |
分类号 |
A61K9/16;A61J3/02;A61K9/50;A61K31/4439;B01J2/00 |
主分类号 |
A61K9/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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