Synthesis of acyloxyalkyl carbamate prodrugs and intermediates thereof
摘要
Methods for synthesis of 1-(acyloxy)-alkyl carbamates, particularly, the synthesis of 1-(acyloxy)-alkyl carbamate prodrugs of primary or secondary amine-containing drugs are described. Also described are methods for synthesis of 1-(acyloxy)-alkyl N-hydroxysuccinimidyl carbonates which are useful intermediates in the synthesis of 1-(acyloxy)-alkyl carbamates.
申请公布号
EP2371815(A1)
申请公布日期
2011.10.05
申请号
EP20110001106
申请日期
2004.12.30
申请人
XENOPORT, INC.
发明人
GALLOP, MARK A.;DAI, XUEDONG;SCHEUERMAN, RANDALL A.;RAILLARD, STEPHEN P.;MANTHATI, SURESH KUMAR;YAO, FENMEI;PHAN, THU;LUDWIKOW, MARIA;PENG, GE;BHAT, SEEMA