发明名称 |
METHODS FOR DETERMINING THE EFFICACY OF PD-1 ANTAGONISTS |
摘要 |
PD-1 antagonists are disclosed that can be used to reduce the expression or activity of PD-1 in a subject. An immune response specific to an infectious agent or to tumor cells can be enhanced using these PD-1 antagonists in conjunction with an antigen from the infectious agent or tumor. Thus, subjects with infections, such as persistent infections can be treated using PD-1 antagonists. In addition, subjects with tumors can be treated using the PD-1 antagonists. In several examples, subjects can be treated by transplanting a therapeutically effective amount of activated T cells that recognize an antigen of interest and by administering a therapeutically effective amount of a PD-1 antagonist. Methods are also disclosed for determining the efficacy of a PD-1 antagonist in a subject administered the PD-1 antagonist. In some embodiments, these methods include measuring proliferation of memory B cells in a sample from a subject administered the PD-1 antagonist. |
申请公布号 |
EP2370593(A2) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20090829832 |
申请日期 |
2009.11.27 |
申请人 |
EMORY UNIVERSITY;DANA-FARBER CANCER INSTITUTE, INC. |
发明人 |
AHMED, RAFI;AMARA, RAMA;VELU, VIJAYAKUMAR;TITANJI, KEHMIA;FREEMAN, GORDON |
分类号 |
A61K39/39;A61K39/00;A61K39/395;C07K16/28;G01N33/50;G01N33/569 |
主分类号 |
A61K39/39 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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