发明名称 |
MODULATION OF BACTERIAL QUORUM SENSING WITH SYNTHETIC LIGANDS |
摘要 |
The present invention provides compounds and methods for modulation of the quorum sensing of bacteria. In an embodiment, the compounds of the present invention are able to act as replacements for naturally occurring bacterial quorum sensing ligands in a ligand-protein binding system; that is, they imitate the effect of natural ligands and produce an agonistic effect. In another embodiment, the compounds of the present invention are able to act in a manner which disturbs or inhibits the naturally occurring ligand-protein binding system in quorum sensing bacteria; that is, they produce an antagonistic effect. The compounds of the present invention comprise N-acylated-homoserine lactones (AHLs) comprised of a wide range of acyl groups. |
申请公布号 |
EP2136800(A4) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20080732506 |
申请日期 |
2008.03.19 |
申请人 |
WISCONSIN ALUMINI RESEARCH FOUNDATION |
发明人 |
BLACKWELL, HELEN E.;GESKE, GRANT D.;O'NEILL, JENNIFER C. |
分类号 |
A61K31/365;C07D309/30 |
主分类号 |
A61K31/365 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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