发明名称 |
Antagonists of miRNA-29 expression and their use in the prevention and treatment of aortic aneurysms and atherosclerotic plaque destabilization |
摘要 |
The present invention relates to antagonists of the expression and/or the function of the micro RNA miRNA-29 for use in the prevention and/or treatment of aortic aneurysms and/or plaque destabilization in atherosclerosis. Further disclosed is a method for the identification of miRNA-29 antagonists, a pharmaceutical composition comprising said miRNA-29 antagonists and a method for preventing and treating age-related aortic aneurysm formation and/or plaque destabilization in atherosclerosis in a subject in need of such a treatment. |
申请公布号 |
EP2371370(A1) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20100003675 |
申请日期 |
2010.04.01 |
申请人 |
JOHANN WOLFGANG GOETHE-UNIVERSITAET FRANKFURT AM MAIN |
发明人 |
ZEIHER, ANDREAS;DIMMELER, STEFANIE;BOON, REINIER |
分类号 |
A61K31/7088;A61P9/10 |
主分类号 |
A61K31/7088 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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