发明名称 |
REPLICATION COMPETENT VIRUSES CAPABLE OF SILENCING VIRUS INHIBITORY FACTOR EXPRESSION |
摘要 |
Described is a replication competent virus, being capable to replicate and having lytic capacity in target cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor. |
申请公布号 |
EP1749097(B1) |
申请公布日期 |
2011.10.05 |
申请号 |
EP20050732404 |
申请日期 |
2005.04.15 |
申请人 |
VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG |
发明人 |
CARETTE, JAN, EDUARD;VAN BEUSECHEM, VICTOR, WILLEM |
分类号 |
C12N15/113;A61K48/00;C12N15/11;C12N15/861 |
主分类号 |
C12N15/113 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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