发明名称 REPLICATION COMPETENT VIRUSES CAPABLE OF SILENCING VIRUS INHIBITORY FACTOR EXPRESSION
摘要 Described is a replication competent virus, being capable to replicate and having lytic capacity in target cells, the virus comprising in the genome thereof, at least one DNA sequence coding for a silencing factor functional in reducing expression of a target gene in the said target cells, operably linked to one or more expression control sequences, functional in the said target cells, and the use thereof in the preparation of a medicament and to the use thereof in a method for lysing target cells expressing a virus inhibitory factor.
申请公布号 EP1749097(B1) 申请公布日期 2011.10.05
申请号 EP20050732404 申请日期 2005.04.15
申请人 VERENIGING VOOR CHRISTELIJK HOGER ONDERWIJS, WETENSCHAPPELIJK ONDERZOEK EN PATIENTENZORG 发明人 CARETTE, JAN, EDUARD;VAN BEUSECHEM, VICTOR, WILLEM
分类号 C12N15/113;A61K48/00;C12N15/11;C12N15/861 主分类号 C12N15/113
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