| 摘要 |
<p>Use of metformin and glyburide for the preparation of a pharmaceutical composition comprising a low dose of a combination of metformin and glyburide intended for first line treatment of type 2 diabetes in drug naive human patients, where the combination contains 250 mg metformin and 1.25 mg glyburide, is intended for administration and has given particles distribution of glyburide. A method for treating diabetes in drug naive human patients is also provided employing the above formulation to reduce insulin resistance and/or post-prandial glucose excursion and/or hemoglobin 1Ac, and/or increase post-prandial insulin, thereby treating the diabetes.</p> |
