1-AZA-BICYCLO(3.3.1) NONANES

摘要

The present invention relates to 1-aza-bicycloalkyl derivatives of formula (1)
wherein
A represents O or N(R 1 );
Y represents a group of formula
wherein the left bond is attached to the A group and the right bond is attached to the R group;
R represents a substituted or unsubstituted C 5 -C 10 aryl, substituted or unsubstituted hetero-C 5 -C 10 aryl, a group N(R 1 )(R 4 ), or a group N(R 2 )(CHR 3 R 4 );
R 1 represents hydrogen, C 1 -C 4 alkyl, or CF 3 ;
R 2 represents hydrogen, C 1 -C 4 alkyl, or CF 3 ;
R 3 represents hydrogen, C 1 -C 4 alkyl, or CF 3 ;
R 4 represents a substituted or unsubstituted C 5 -C 10 aryl or a substituted or unsubstituted C 5 -C 10 heteroaryl;
in free base or acid addition salt form.