| 摘要 |
Disclosed is an anti-VAP-1 antibody or VAP-1 binding fragment thereof, comprising a heavy chain polypeptide, wherein the heavy chain polypeptide comprises, in the following order, the CDR sequences set forth as SEQ ID NOs: 1, 2, and 3, and a light chain polypeptide comprising, in the following order, the CDR sequences set forth as SEQ ID NOs: 24, 25, and 26, characterized in that it is fully human. Also disclosed is The use of the antibody for the preparation of an agent useful for treating or diagnosing a VAP-1 mediated inflammatory disorder in a patient in need thereof, wherein said VAP-1 mediated inflammatory disorder is selected from the group consisting of arthritides and connective tissue diseases, inflammatory bowel diseases, dermatoses, multiple sclerosis, inflammatory neuropathy, inflammatory myopathy, acute disseminated encephalomyelitis, vasculitis of the central nervous system, Sjögrens syndrome, diabetes, systemic lupus erythematosus, asthma, inflammatory liver disease, Graves disease and thyroiditis.
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