发明名称 |
COMPOSITIONS AND METHODS FOR USING MULTISPECIFIC-BINDING PROTEINS COMPRISING AN ANTIBODY-RECEPTOR COMBINATION. |
摘要 |
<p>Disclosed are bispecific binding proteins comprising a antibody/soluble receptor bispecific binding protein that reduces the biological activity of both VEGF-A and FGF. The FGF binding moieties are generally soluble FGFR3 or FGFR2. An Fc polypeptide is fused to the C-terminus of the FGF binding moiety and VEGF-A binding moiety are polypeptides fused using peptide or polypeptide linker sequences, and can be expressed as single bispecific binding protein. The bispecific antibody/soluble receptor binding proteins can be used to treat cancers characterized by solid tumor growth as well as other diseases.</p> |
申请公布号 |
MX2011009810(A) |
申请公布日期 |
2011.09.30 |
申请号 |
MX20110009810 |
申请日期 |
2010.03.26 |
申请人 |
ZYMOGENETICS, INC. |
发明人 |
PALLAVUR V. SIVAKUMAR;QI PAN;CARL W. BIRKS |
分类号 |
C07K14/71;A61K39/395;C07K16/22;C12N15/62 |
主分类号 |
C07K14/71 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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