| 摘要 |
DISCLOSED ARE NOVEL METHODS FOR COMBATTING DISEASES CHARACTERIZED BY DEPOSITION OF AMYLOID. THE METHODS GENERALLY RELY ON IMMUNIZATION AGAINTS AMYLOID PRECURSOR PROTEIN (APP) OR BETA AMYLOID (Aß). IMMUNIZATION IS PREFERABLY EFFECTED BY ADMINISTRATION OF ANALOGUES OF AUTOLOGOUS APP OR Aß, SAID ANALOGUES BEING CAPABLE OF INDUCING ANTIBODY PRODUCTION AGAINTS THE AUTOLOGOUS AMYLOIDOGENIC POLYPEPTIDES. ESPECIALLY PREFERRED AS AN IMMUNOGEN IS AUTOLOGOUS Aß WHICH HAS BEEN MODIFIED BY INTRODUCTION OF ONE SINGLE OR A FEW FOREIGN, IMMUNODOMINANT AND PROMISCUOUS T-CELL EPITOPES. ALSO DISCLOSED ARE NUCLEIC ACID VACCINATION AGAINTS APP OR Aß AND VACCINATION USING LIVE VACCINES AS WELL AS METHODS AND MEANS USEFUL FOR THE VACCINATION. SUCH METHODS AND MEANS INCLUDE METHODS FOR THE PREPARATION OF ANALOGUES AND PHARMACEUTICAL FORMULATIONS, AS WELL AS NUCLEIC ACID FRAGMENTS, VECTORS, TRANSFORMED CELLS, POLYPEPTIDES AND PHARMACEUTICAL FORMULATIONS. |
