| 发明名称 |
ZAP-70 EXPRESSION AS A MARKER FOR CHRONIC LYMPHOCYTIC LEUKEMIA / SMALL LYMPHOCYTIC LYMPHOMA (CLL/SLL) |
| 摘要 |
It has been surprisingly found that ZAP-70 expression, both at the protein and mRNA levels, is indicative of clinical subgroups of CLL/SLL patients. In particular, high ZAP-70 expression is indicative of Ig-unmutated CLL/SLL. Methods are provided for discriminating between clinical subgroups of CLL/SLL, by determining whether subjects overexpress ZAP-70 mRNA mRNA or protein.
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| 申请公布号 |
US2011236915(A1) |
申请公布日期 |
2011.09.29 |
| 申请号 |
US201113155198 |
申请日期 |
2011.06.07 |
| 申请人 |
THE GOVERNMENT OF USA AS REPRESENTED BY THE SECRETARY OF THE DEP'T OF HEALTH AND HUMAN SERVICE |
发明人 |
STAUDT LOUIS M.;ROSENWALD ANDREAS;WILSON WYNDHAM;BARRY TODD S.;WIESTNER ADRIAN |
| 分类号 |
G01N33/53;C12N15/11;C12Q1/48;C12Q1/68;G01N33/543;G01N33/574 |
主分类号 |
G01N33/53 |
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