发明名称 |
Protein Formulation |
摘要 |
A stable lyophilized protein formulation is described which can be reconstituted with a suitable diluent to generate a high protein concentration reconstituted formulation which is suitable for subcutaneous administration. For example, anti-IgE and anti-HER2 antibody formulations have been prepared by lyophilizing these antibodies in the presence of a lyoprotectant. The lyophilized mixture thus formed is reconstituted to a high protein concentration without apparent loss of stability of the protein.
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申请公布号 |
US2011236383(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113156113 |
申请日期 |
2011.06.08 |
申请人 |
ANDYA JAMES;CLELAND JEFFREY L;HSU CHUNG C;LAM XANTHE M;OVERCASHIER DAVID E;SHIRE STEVEN J;YANG JANET YU-FENG;WU SYLVIA SAU-YAN |
发明人 |
ANDYA JAMES;CLELAND JEFFREY L.;HSU CHUNG C.;LAM XANTHE M.;OVERCASHIER DAVID E.;SHIRE STEVEN J.;YANG JANET YU-FENG;WU SYLVIA SAU-YAN |
分类号 |
A61K39/395;A61K38/16;A61P43/00;B65D69/00;C07K16/42 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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