发明名称 Use of Statins to Inhibit Inflammation and Vascular Disease
摘要 The current invention discloses novel methods for the inhibition of inducible nitric oxide synthesis (iNOS) and the production of NO. Methods of inhibiting the induction of proinflammatory cytokines are also described. Methods of treating various disease states, such as X-linked adrenoleukodystrophy, multiple sclerosis, Alzheimer's and septic shock using inhibitors of iNOS and cytokine induction are disclosed. The inhibitors include the exemplary compounds lovastatin, a sodium salt of phenylacetic acid (NaPA), FPT inhibitor II, N-acetyl cysteine (NAC), and cAMP.
申请公布号 US2011237662(A1) 申请公布日期 2011.09.29
申请号 US201113117675 申请日期 2011.05.27
申请人 MUSC FOUNDATION FOR RESEARCH DEVELOPMENT 发明人 SINGH INDERJIT
分类号 A61K31/366;A61K31/00;A61K31/137;A61K31/145;A61K31/175;A61K31/192;A61K31/198;A61K31/20;A61K31/275;A61K31/343;A61K31/35;A61K31/352;A61K31/40;A61K31/4015;A61K31/4196;A61K31/472;A61K31/522;A61K31/661;A61K31/7056;A61K31/7076;A61P9/10;A61P9/12;C12N9/99 主分类号 A61K31/366
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