发明名称 |
FLAVIVIRUS HOST RANGE MUTATIONS AND USES THEREOF |
摘要 |
Methods and compositions concerning mutant flaviviruses with host range mutations. In some embodiments the invention concerns nucleotide sequences that encode mutant flavivirus proteins. Viruses comprising these sequences that display reduced replication in mammalian cells are provided. In further aspects of the invention, flavivirus vaccine compositions are provided. In another embodiment the invention provides methods for vaccination against flavivirus infection.
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申请公布号 |
US2011236421(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113069905 |
申请日期 |
2011.03.23 |
申请人 |
BROWN DENNIS T;HERNANDEZ RAQUEL;THOMAS MALCOLM E;SMITH KATHERINE M;NANDA KAVITA |
发明人 |
BROWN DENNIS T.;HERNANDEZ RAQUEL;THOMAS MALCOLM E.;SMITH KATHERINE M.;NANDA KAVITA |
分类号 |
A61K39/12;A61P31/14;A61P37/04;C07H21/00;C07K14/18;C12N7/01 |
主分类号 |
A61K39/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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