NOVEL PEPTIDES AND METHODS FOR THEIR PREPARATION AND USE
摘要
The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide- 1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.
申请公布号
WO2011119657(A1)
申请公布日期
2011.09.29
申请号
WO2011US29501
申请日期
2011.03.23
申请人
ELI LILLY AND COMPANY;ALSINA-FERNANDEZ, JORGE;BOKVIST, KRISTER BENGT;GUO, LILI;MAYER, JOHN PHILIP
发明人
ALSINA-FERNANDEZ, JORGE;BOKVIST, KRISTER BENGT;GUO, LILI;MAYER, JOHN PHILIP