发明名称 |
USE OF ANATABINE TO TREAT INFLAMMATION AND METHODS OF SYNTHESIZING ANATABINE |
摘要 |
Pharmaceutical compositions comprising an isolated form of anatabine or a salt thereof can be used to treat disorders comprising an inflammatory component, including chronic, low-level inflammation. In another aspect, methods for the synthetic preparation of anatabine involve reacting benzophenoneimine with 3-aminomethyl pyridine to form benzylhydrylidene-pyridin-3-yl-methyl-amine. The benzylhydrylidene-pyridin-3-yl-methyl-amine is treated with a non-nucleophilic base and a dielectrophile, such as cis-1,4-dichloro-2-butene, followed by acidification, then basification, to provide anatabine. |
申请公布号 |
WO2011119722(A2) |
申请公布日期 |
2011.09.29 |
申请号 |
WO2011US29613 |
申请日期 |
2011.03.23 |
申请人 |
ROCK CREEK PHARMACEUTICALS, INC.;WILLIAMS, JONNIE R.;PUTHIAPARAMPIL, TOM THOMAS;DAVID, THOMAS KANATHKUNN;RAJU, MUPPALA SARVESWARA |
发明人 |
WILLIAMS, JONNIE R.;PUTHIAPARAMPIL, TOM THOMAS;DAVID, THOMAS KANATHKUNN;RAJU, MUPPALA SARVESWARA |
分类号 |
A61K31/4458;A61P29/00 |
主分类号 |
A61K31/4458 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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