<p>The present invention provides humanised antibodies and binding domains thereof with anti-tumour activity. In particular the humanised antibodies have specific binding to and direct killing of human colon tumour cells and display potent immune-mediated cytotoxic activity against human colon cancer cells in vitro using antibody-dependent cell-mediated cytotoxicity (ADCC) and complement dependent cytotoxicity (CDC) assays and in vivo using mouse tumour models.</p>
申请公布号
SG173577(A1)
申请公布日期
2011.09.29
申请号
SG20110056751
申请日期
2010.03.16
申请人
CEPHALON AUSTRALIA PTY LTD
发明人
KIENZLE, NORBERT, ALEXANDER;CLARKE, ADAM, WILLIAM;DOYLE, ANTHONY, GERARD;JENNINGS, PHILIP, ANTHONY;POLLARD, MATTHEW