METHOD OF PREPARING A GRANULATED PHARMACEUTICAL COMPOSITION COMPRISING SIMVASTATIN AND/OR EZETIMIBE
摘要
<p>A method of preparing a granulated pharmaceutical composition by wet granulation, which method comprises: (a) suspending one or more pharmaceutically active ingredients comprising statin or ezetimibe or both statin and ezetimibe in a granulating liquid to form a granulating suspension; (b) optionally subjecting the granulating suspension of step (a) to high pressure homogenisation; (c) adding the granulating suspension of step (a) or (b) to a composition comprising one or more pharmaceutically acceptable inactive ingredients; and (d) granulating the mixture of step (c), as well as pharmaceutical compositions obtained by this process.</p>
申请公布号
WO2011116973(A1)
申请公布日期
2011.09.29
申请号
WO2011EP01491
申请日期
2011.03.24
申请人
KRKA, TOVARNA ZDRAVIL, D.D., NOVO MESTO;VRECER, FRANC;BUKOVEC, POLONA;GERMAN, TAMARA