| 发明名称 |
METHOD FOR PRODUCING (TRIFLUOROMETHYL) ALKYL KETONE |
| 摘要 |
PROBLEM TO BE SOLVED: To provide a method for producing a (trifluoromethyl) alkyl ketone in a high yield in a few steps under mild reaction conditions. SOLUTION: The method for producing a (trifluoromethyl) alkyl ketone represented by formula (A) includes the following steps of (i) a step for reacting magnesium with a compound represented by formula R<SP>1</SP>Br (wherein R<SP>1</SP>is alkyl) to give R<SP>1</SP>MgBr (wherein R<SP>1</SP>is as shown above) in the presence of a (cycloalkyl) alkyl ether, (ii) a step for reacting the compound represented by formula R<SP>1</SP>MgBr (wherein R<SP>1</SP>is as shown above) with a compound represented by formula CF<SB>3</SB>COOR<SP>2</SP>(wherein R<SP>2</SP>is ester residue) in the presence of a (cycloalkyl) alkyl ether to give a Grignard reagent adduct and (iii) a step for hydrolyzing the adduct to give the (trifluoromethyl) alkyl ketone represented by formula (A). COPYRIGHT: (C)2011,JPO&INPIT
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| 申请公布号 |
JP2011190216(A) |
申请公布日期 |
2011.09.29 |
| 申请号 |
JP20100058030 |
申请日期 |
2010.03.15 |
| 申请人 |
ASAHI GLASS CO LTD |
发明人 |
OGAWA HAJIME;ASAI TOMOYUKI |
| 分类号 |
C07C45/42;C07C49/167;C07F3/02 |
主分类号 |
C07C45/42 |
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