发明名称 |
NOVEL PEPTIDES AND METHODS FOR THEIR PREPARATION AND USE |
摘要 |
The present invention is in the field of treatment of diabetes and relates to peptides that exhibit activity for both glucose-dependent insulinotropic peptide receptor (GIP-R) and glucagon-like peptide-1 receptor (GLP-1-R) and are selective over glucagon receptor (Gluc-R). Specifically provided are GIP analogs with amino acid substitutions introduced to modulate activity for both GIP-R and GLP-1-R and maintain selectivity over Gluc-R.
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申请公布号 |
US2011237503(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113069425 |
申请日期 |
2011.03.23 |
申请人 |
ELI LILLY AND COMPANY |
发明人 |
ALSINA-FERNANDEZ JORGE;BOKVIST KRISTER BENGT;GUO LILI;MAYER JOHN PHILIP |
分类号 |
A61K38/22;A61P3/04;A61P3/10;C07K14/575 |
主分类号 |
A61K38/22 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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