发明名称 |
Method Involving 1-Benzotriazolyl Carbonate Esters of Polymers |
摘要 |
The invention provides a method comprising the steps of (i) reacting a water-soluble and non-peptidic polymer having two or more terminal hydroxyl groups with di(1-benzotriazolyl)carbonate to form a water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups; and (ii) reacting the water-soluble and non-peptidic polymer having two or more 1-benzotriazolylcarbonate ester groups with a water-soluble and non-peptidic polymer having three or more primary amino groups under conditions effective to form a cross-linked polymer composition. |
申请公布号 |
US2011237746(A1) |
申请公布日期 |
2011.09.29 |
申请号 |
US201113154917 |
申请日期 |
2011.06.07 |
申请人 |
NEKTAR THERAPEUTICS |
发明人 |
KOZLOWSKI ANTONI |
分类号 |
C08G65/48;C12N9/96;A61K47/48;C08F8/30;C08G65/325 |
主分类号 |
C08G65/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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